Elevated FDP levels independently predict poor outcomes in HBV-ACLF patients treated with artificial liver support system therapy.

ABSTRACT: Acute-on-chronic liver failure (ACLF) is an extremely severe clinical syndrome, often associated with systemic inflammation, coagulation dysfunction, and fibrinolysis abnormalities. Fibrin degradation product (FDP), as a byproduct of fibrinolysis, is a crucial indicator reflecting the state of fibrinolysis. The objective of this study is to investigate the relationship between FDP levels and the 28-day mortality rate in patients with ACLF. We retrospectively enrolled 520 patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) who underwent artificial liver support system therapy and collected relevant clinical data at admission. Cox regression analysis was employed to investigate the relationship between FDP levels and the 28-day mortality rate, and the predictive

SUBMITTER: Yang X 

PROVIDER: S-EPMC12635316 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature