Discriminating between proposed Brain-First and Body-First Parkinson's disease using conventional and radiomics-enhanced dopamine transporter SPECT image analysis.

ABSTRACT: Two Parkinson's disease subtypes-"Brain-First" and "Body-First"-have been proposed based on putative sites of onset. We examined whether "Body-First" markers relate to more symmetric striatal [¹²³I]-FP-CIT uptake and whether imaging could discriminate the subtypes. In a retrospective cohort of 158 de novo PD patients imaged at diagnosis and followed for six years, patients were classified as "Body-First" if baseline REM sleep behavior disorder, constipation, or neurogenic orthostatic hypotension was present. DaTQUANT provided semiquantitative metrics; a radiomics-based classifier was also trained on DAT-SPECT images. Neither asymmetry indices nor other DaTQUANT measures differed between groups (all p > 0.05). Radiomics showed poor discrimination (AUC ≈ 0.46). Clinically, "Body-F

SUBMITTER: Palermo G 

PROVIDER: S-EPMC12635385 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature