Glucose-functionalized gold nanoparticles for effective photothermal therapy in lung cancer.

ABSTRACT: Lung cancer remains the leading cause of cancer-related mortality worldwide, largely due to late-stage diagnoses that severely limit therapeutic interventions. In this context, nanoparticle-mediated photothermal therapy (PTT) has emerged as a promising and minimally toxic modality for solid tumors. We synthesized gold nanoparticles (AuNPs) with three distinct morphologies-spheres, rods, and stars-and functionalized them with polyethylene glycol (AuNPs-PEG) or polyethylene glycol conjugated with 2-deoxy-D-glucose (AuNPs-Gluc). In vitro analyses using human (A549, H1299) and murine (LLC) lung carcinoma cell lines demonstrated that PEGylation significantly attenuated AuNP-associated cytotoxicity, while glucose functionalization further enhanced biocompatibility. Inductively coupled plasma mas

SUBMITTER: Menendez JB 

PROVIDER: S-EPMC12635407 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature