Severe obesity associates with maladaptive glomerular haemodynamics clustered with insulin resistance and endothelial dysfunction.

ABSTRACT:

Background

Obesity is a leading risk factor for chronic kidney disease, with glomerular hyperfiltration as one of its earliest manifestations. However, absolute glomerular filtration rate (GFR) does not distinguish well between a pressure-driven hyperfiltration and the physiological forms. Insulin resistance and endothelial dysfunction have been proposed as key correlates of maladaptive renal haemodynamics, but their interplay remains unclear.

Methods

Cross-sectional pilot study involving 27 adults with severe obesity (mean body mass index of 43.9 kg/m²). Measured GFR (mGFR) was assessed by iohexol plasma clearance and effective renal plasma flow (ERPF) by ¹²³I-ortho-iodohippurate clearance. A hyperfiltration index (P-score) was derived as the standardized differe

SUBMITTER: Moriconi D 

PROVIDER: S-EPMC12635466 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature