Familial risk of Wolff-Parkinson-White syndrome: a nationwide family study in Sweden.

ABSTRACT:

Aims

Wolff-Parkinson-White (WPW) syndrome is a rare cardiac disorder that predisposes to supraventricular arrhythmias. Prognosis is usually benign, yet there is an increased lifetime risk of sudden death. While typically sporadic, familial clustering has been reported. This study aimed to assess the risk of WPW, arrhythmias, and mortality among siblings of individuals with WPW.

Methods and results

This population-based sibling cohort included 5 338 434 individuals born in Sweden (1932-2018), with 3172 WPW cases identified from the Swedish National Patient Registers. Familial risks among siblings were assessed using incidence rate ratios (IRRs) and adjusted subdistributional hazard ratios (SHRs). Sensitivity analyses excluded syndromic WPW and cases without electrophysiologic

SUBMITTER: Ricci F 

PROVIDER: S-EPMC12635823 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature