Brain rewiring during development: A comparative analysis of larval and adult <i>Drosophila melanogaster</i> connectomes.

ABSTRACT: The brain's ability to undergo complex rewiring during development is a fascinating aspect of neuroscience. This study conducts a detailed comparison of Drosophila melanogaster's brain networks during larval and adult stages, revealing significant changes in neuronal wiring throughout development. The larval brain network exhibits a degree distribution that fits firmly to a Weibull model. In contrast, the sparser adult brain network follows a power-law distribution, with the out-degree exponent lying in the scale-free regime and the in-degree exponent close to it. This shift toward a scale-free pattern likely reflects an adaptation to enhance robustness against failures while minimizing costs associated with reduced density during development. We also observed alterations in the str

SUBMITTER: Yadav P 

PROVIDER: S-EPMC12635837 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature