Apolipoprotein E and Alzheimer's disease pathology in a diverse autopsy study.

ABSTRACT:

Introduction

Apolipoprotein E allele 4 (APOE ε4) is the main genetic risk factor for late-onset Alzheimer's disease (AD), but most evidence comes from White populations in high-income countries. We investigated APOE and AD pathology in an ethnically diverse Brazilian autopsy cohort.

Methods

This cross-sectional study used Biobank for Aging Studies (BAS) data. AD pathology was evaluated with Braak, Consortium to Establish a Registry for Alzheimer's Disease, and Thal criteria. APOE genotypes were obtained from blood or brain tissue. Regression models were adjusted for age, sex, race, and education; interaction with race was tested.

Results

Among 1391 participants (mean age 75.1 ± 12.4 years, 50% women, 64% White), APOE ε4showed a dose response with greater AD pathologic

SUBMITTER: Suemoto CK 

PROVIDER: S-EPMC12635860 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature