Alzheimer's disease multi-ancestry genome-wide interaction and stratified study with smoking.

ABSTRACT:

Introduction

Alzheimer's disease (AD) has genetic and environmental risk factors, including cigarette smoking. Gene-environment interactions may explain AD missing heritability.

Methods

Lifetime smoking data from 22,032 European ancestry and 3126 African ancestry participants from the Alzheimer's Disease Genetic Consortium and the Framingham Heart Study were used to conduct genome-wide single nucleotide polymorphism (SNP)-by-smoking interaction and smoking-stratified association studies. For top-ranked loci, brain-derived bulk and single nuclei RNA-sequencing were used for differential expression and colocalization analyses.

Results

Among smokers only, there was a genome-wide significant association in the APAF1/ANKS1B region (rs12368451; odds ratio = 1.19, 95% confid

SUBMITTER: Dacey R 

PROVIDER: S-EPMC12635870 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature