Role of Adipose Tissue Compartments for Cardiovascular Risk in Diabetes Endotypes.

ABSTRACT:

Objective

The severe insulin-resistant diabetes (SIRD) endotype is associated with metabolic dysfunction-associated steatotic liver disease and higher cardiovascular risk. We investigated whether skeletal muscle or adipose tissue lipids are elevated in SIRD.

Research design and methods

Participants (N = 420) of the German Diabetes Study (GDS) were assigned to diabetes clusters using a validated algorithm. 1H-magnetic resonance methods were used to quantify intramyocellular lipids (IMCLs), intrahepatic lipids (IHLs), and visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) volumes.

Results

Aside from elevated IHLs (P < 0.01), SIRD showed higher VAT and SAT than other endotypes after adjustment for BMI (all P < 0.05) but not for multiple comparisons. All

SUBMITTER: Zaharia OP 

PROVIDER: S-EPMC12635897 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature