Iron Metabolism Disorders Associated With the Severity of Pyogenic Liver Abscess.

ABSTRACT: Pyogenic liver abscess (PLA) is a serious intra-abdominal infection with high morbidity and mortality. Current diagnostic methods are time-consuming, inefficient and high-cost. Rapid identification/assessment of PLA and early recognition of bacterial liver abscess (BLA) improve prognosis. Iron metabolism disorders play a critical role in infections, but their role in PLA (especially ferritin) remains unclear. Notably, dietary nutrition, as a modulator of iron metabolism/immune function, may influence PLA progression, with limited research. In this study, we collected clinical data of 125 PLA patients from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database to identify rapid, low-cost severity biomarkers, and verified them by an independent clinical cohort of 36 patients

SUBMITTER: Han Z 

PROVIDER: S-EPMC12635943 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature