Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes.

ABSTRACT:

Objective

Despite the use of multiple glucose-lowering medications, glycemic targets are not met in a significant fraction of people with type 2 diabetes. In this prospective, observational study we assessed the prevalence of hypercortisolism, a potential contributing factor to inadequate glucose control.

Research design and methods

Individuals with type 2 diabetes and HbA1c 7.5%-11.5% (58-102 mmol/mol) on two or more glucose-lowering medications with or without micro-/macrovascular complications or taking multiple blood pressure-lowering medications were screened with a 1-mg dexamethasone suppression test. Common causes of false-positive DSTs were excluded. The primary end point was the prevalence of hypercortisolism, defined as post-DST cortisol >1.8 μg/dL (50 nmol/L). Cha

SUBMITTER: Buse JB 

PROVIDER: S-EPMC12635953 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature