Polypept(o)ide Based Biodegradable Cylindrical Polymer Brushes: Controlling Size, Shape, Surface Functionality, and Stability.

ABSTRACT: Cylindrical polymer brushes (CPBs) enable remarkable control over nanoparticle properties solely through sequential polymerization. The spatial dimensions and functionality of the resulting polymeric nanoparticles can be adjusted by the ratio of backbone to side chain length and the chemical nature of both parts. In this work, we present a convenient and straightforward synthetic pathway to polypept(o)ide-based CPBs using a "grafting-from" strategy utilizing poly-l-lysine (pLys) as the macroinitiator backbone and polysarcosine (pSar) as the side chain. End-capping of pSar chains with azido-butyric acid pentafluorophenyl ester enables facile surface functionalization by click chemistry (e.g., dye labeling). This strategy allows for straightforward control over nanoparticle size (R

SUBMITTER: Seidl CI 

PROVIDER: S-EPMC12635966 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature