Thermo-Magnetic Induction of Pro-Inflammatory Microglia: A Lipid-Based Nanovector Strategy for Glioblastoma Immunotherapy.

ABSTRACT: Microglia, the main immune cells in the central nervous system (CNS), maintain physiological homeostasis and react to pathological changes. Besides their neuroprotective function, they play a crucial role in brain tumor microenvironments such as glioblastoma (GBM), by composing up 40% of the tumor mass. Glioma-associated microglia exhibit a dynamic activation state characterized mainly by an immunosuppressive (M2-like) response, with a lesser contribution of pro-inflammatory (M1-like) response. Modulating microglial into M1-like phenotype offers antitumor response and a promising immunotherapy strategy against GBM. Nanoparticles can induce microglial polarization, also modulating pro-inflammatory responses for tumor suppression. Magnetically responsive nanoparticles are promising nanotrans

SUBMITTER: Ceccarelli MC 

PROVIDER: S-EPMC12635967 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature