Advancing Medical Diagnostics: Rapid, Label-Free Detection and Differentiation of Shiga Toxin Variants in Human Serum Using a Cost-Effective PCA-Assisted SERS Platform.

ABSTRACT: Shiga toxins-producing Escherichia coli (STEC) are zoonotic pathogens causing severe diseases such as hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS). Infections caused by STEC represent a public health concern due to the severity of the possible outcome and acute mortality. The early diagnosis of the infection is pivotal to driving a correct therapeutic protocol to limit the severity of the symptoms. The diagnosis is quite cumbersome, requires specialized approaches, and thus is rarely performed in the hospital, being managed by the relevant national reference laboratory, delaying the administration of the appropriate supportive care. In this context, the demand for affordable diagnostic tests to be carried out at the bedside is crucial for providing high-value healthc

SUBMITTER: Milano A 

PROVIDER: S-EPMC12635968 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature