Engineered Nanofiber-Hydrogel Systems for Colorimetric Lactate Sensing from Breath.

ABSTRACT: Current methods for detecting chronic airway inflammation, such as asthma, rely on complex procedures and specialized clinicians. Taking advantage of inherent nanomaterial properties and their chemical design flexibility, nanofibers were designed and integrated with enzyme entrapping hydrogels. This composition offers noninvasive sample collection followed by simple colorimetric detection. Specifically, nanofibers were made from positively charged nylon-poly(allylamine hydrochloride). They were optimized with respect to mat thickness, additive content, and lactate capture efficiency. The nanofibers could efficiently bind lactate through electrostatic interaction, correlating the resulting amount on the nanofiber mat to the concentration in breath aerosols. Detection was subsequently accomp

SUBMITTER: Grotz BV 

PROVIDER: S-EPMC12635974 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature