Ligand-Controlled Chemodivergent Bismuth Catalysis.

ABSTRACT: Herein, we report a ligand-controlled chemodivergent bismuth-catalyzed coupling between arylboronic acids and N-fluorosulfonimide derivatives that enables the selective formation of either C(sp²)-N or C(sp²)-O bonds. Selectivity is achieved by the modulation of the electronic and steric properties of a common ligand framework for bismuth, thus establishing an unusual ligand-controlled chemodivergent platform in main group catalysis. Specifically, the use of an electron-enrich sulfone ligand led to the major formation of sulfonimide with selectivities ranging from 2:1 to more than 20:1. Conversely, a bismuth catalyst supported by an electron-deficient sulfoximine predominantly promoted the sulfonimidate product with ratios ranging between 5:1 and 15:1. To unders

SUBMITTER: Mele L 

PROVIDER: S-EPMC12636031 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature