Time-Restricted Access to High-Fat Diet Influences Weight Gain, Meal Patterns, and Food Preference.

ABSTRACT:

Objective

Access to only high-fat diet (HFD) during the light versus dark cycle promotes different metabolic outcomes. We assessed changes in body weight/composition, feeding behavior, and metabolic parameters in mice fed HFD during the light or dark cycle with concomitant ad libitum access to chow.

Methods

Male C57BL/6J mice were housed in metabolic chambers with two hoppers containing chow. HFD was then provided in one hopper, with access restricted to the light or dark cycle. The other hopper provided ad libitum access to chow. Food intake, meal patterns, energy expenditure, activity, and substrate oxidation were measured for ~4 weeks. Body weight/composition was measured before and after ~4-week HFD access.

Results

Light cycle HFD access promoted greater weight an

SUBMITTER: Fathi PA 

PROVIDER: S-EPMC12636058 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature