Association of BMI and Cognitive Performance in the Diabetes Prevention Program Outcomes Study.

ABSTRACT:

Objective

This study aimed to examine the association of BMI with cognitive performance in individuals with diabetes or prediabetes.

Methods

Among Diabetes Prevention Program Outcomes Study (DPPOS) participants, BMI was categorized as normal (< 25 kg/m²), overweight (25 to < 30 kg/m²), or obesity (≥ 30 kg/m²). Cognitive tests included the Brief Spanish English Verbal Learning Test (B-SEVLT) and the Digit Symbol Substitution test (DSST). The relationship between BMI at DPPOS Year 8 (Y8) visit and cognitive test scores at Y8, Y10, and Y15 visits was ascertained via linear mixed models accounting for repeated measures. Analogous models related BMI to Modified Mini-Mental State exam (3MS) score at Y15.

Results

A total of 2285 participants

SUBMITTER: Luchsinger JA 

PROVIDER: S-EPMC12636062 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature