Genetic Determinants of Fatty Acid Composition in Subcutaneous and Visceral Adipose Tissue.

ABSTRACT:

Objective

Fatty acids in adipose tissue are key structural and metabolic regulators of cardiometabolic health, but the genetic architecture governing depot-specific composition in subcutaneous (SAT) and visceral adipose tissue (VAT) is not well defined.

Methods

We used MRI-derived estimates of fatty acid composition in SAT and VAT from 33,583 UK Biobank participants to perform genome-wide association studies. Functional annotation, fine mapping, colocalization, and expression QTL analyses were conducted to prioritize likely causal variants and explore mechanisms.

Results

We identified six loci associated with adipose tissue fatty acid composition, including both shared (PKD2L1, INSIG1) and depot-specific associations (LEKR1 and KLF14 for SAT; CDCA2 for VAT). The stron

SUBMITTER: Ahmed A 

PROVIDER: S-EPMC12636063 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature