Accurate and Fast Thermal Sensing via Phase-Responsive Nanothermometers and Neural Networks.

ABSTRACT: Accurate, rapid, and remote temperature sensing at the nanoscale is essential for applications ranging from monitoring cellular thermodynamics to thermal management of microelectronic devices. Luminescent nanothermometers are promising candidates; however, their deployment is hindered by limited thermal sensitivity and cross-sensitivity to environmental factors that mimic temperature-induced luminescence changes. We introduce fluorescent chromatic nanoswitchers (CNSs), comprising silica nanocapsules incorporating a fluorescent dye within a thermoresponsive matrix. The matrix undergoes a solid-to-liquid phase transition, yielding an exceptional fluorescence lifetime sensitivity of 19% °C^-1 at 37 °C. Crucially, the lifetime-based thermal readout provided by CNSs is resistant to en

SUBMITTER: Paris-Ogayar M 

PROVIDER: S-EPMC12636073 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature