Inhibiting Monocyte Migration Reduces Arterial Thrombosis and Facilitates Thrombolysis.

ABSTRACT:

Background

Monocytes contribute to the initiation and propagation of venous thrombosis. Little is known about the roles monocytes play in arterial thrombosis, the cause of stroke and myocardial infarction.

Methods

We investigated how CCR2 (CC chemokine receptor 2) knockout (^-/-)-mediated monocyte deficiency affects platelet function, blood coagulation, thrombus volume, and thrombolytic susceptibility in 666 male mice with FeCl₃-mediated carotid arterial thrombosis, including 365 C57BL/6 wild type (WT) mice, 295 CCR2^-/- mice, and 6 CX3CR1-GFP (CX3C chemokine receptor 1-green fluorescent protein) mice.

Results

Intravital microscopy and flow cytometry showed that both neutrophils and monocytes were recruited to the acute arterial thrombus

SUBMITTER: Jang HJ 

PROVIDER: S-EPMC12636086 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature