Risk of ovarian cancer in women with pelvic inflammatory disease and homologous recombination repair gene mutations under 55: a population-based cohort study.

ABSTRACT:

Objective

To address the relation among pelvic inflammatory disease (PID), genetic vulnerability and ovarian cancer (OC) risk, we assessed the association between PID and OC risk, alongside the interplay with germline homologous recombination repair (gHR) mutation, utilizing the UK Biobank.

Methods

We conducted a prospective cohort study in the UK Biobank by tracking OC incidences between individuals with and without a PID history. Identification of gHR mutations (BRCA1, BRCA2, RAD51C, RAD51D, BRIP1) carriers were accomplished through paired whole-exome sequencing data. We used Cox's regression models to evaluate the hazard ratios (HRs) for OC risks under PID.

Results

In the large prospective cohort study, the adjusted HR for OC in p

SUBMITTER: Feng C 

PROVIDER: S-EPMC12636098 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature