Oncogenic pathway landscape of ovarian cancer and correlation with clinical prognosis.

ABSTRACT:

Objective

We aimed to identify the main oncogenic pathway by histological type of ovarian cancer based on Next-generation sequencing (NGS) test and to determine the correlation with clinical prognosis.

Methods

We conducted a retrospective review of 420 patients with ovarian cancer who underwent NGS testing at Asan Medical Center from June 1, 2017, to May 31, 2021. Identified mutations were categorized into seven oncogenic pathways that are most frequently associated with ovarian cancer.

Results

The average number of oncogenic pathways involved in each cancer patient was 1.76 (range, 0-6). TP53 mutation was the primary oncogenic pathway in patients with high-grade serous carcinoma (HGSC) (92.8%) and carcinosarcoma (87.5%). MAP kinase signaling was the primary oncogenic

SUBMITTER: Lee YJ 

PROVIDER: S-EPMC12636105 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature