Selective vulnerability of GABAergic neurons in chronic migraine.

ABSTRACT:

Background

Migraine is the second leading cause of neurological disability and has a strong genetic component. Previous linkage studies have identified a candidate migraine susceptibility locus on chromosome Xq24-28, which harbors several GABA_A receptor subunit genes. Despite its inhibitory role in the central nervous system, the contribution of the GABAergic system to migraine pathophysiology remains insufficiently understood. This study elucidates the role of GABAergic neurons in chronic migraine using established rodent models. We induced basal hypersensitivity as a preclinical model of chronic migraine by administering repeated intraperitoneal injections of nitroglycerin, a well-established migraine trigger, every other day over a nine-day period. Mechanical hypersen

SUBMITTER: Hossain KH 

PROVIDER: S-EPMC12636155 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature