The effect of platelet-rich plasma on clinical outcomes within two years after anterior cruciate ligament reconstruction: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Objective

Although platelet-rich plasma (PRP) has been applied in anterior cruciate ligament reconstruction (ACLR) to promote recovery, the time-dependent efficacy of PRP on postoperative pain, function, and joint stability remains controversial. This study aims to evaluate the clinical effects of PRP at various follow-up intervals within two years after ACLR through a time-stratified meta-analysis.

Methods

A comprehensive literature search was systematically performed across PubMed, Embase, the Cochrane Library, and Web of Science databases. Outcome measures included the Visual Analogue Scale (VAS), Lysholm score, International Knee Documentation Committee (IKDC) score, Tegner activity score, and KT-1000 arthrometer readings. Standardized mean differences (SMDs) with corres

SUBMITTER: Li G 

PROVIDER: S-EPMC12636180 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature