Immunomodulatory interventions in type 1 diabetes: a systematic review and meta-analysis revealing paradoxical dissociation between beta-cell preservation and glycemic control.

ABSTRACT:

Background

Immunomodulatory therapies aim to preserve beta-cell function in type 1diabetes (T1D), yet their clinical translation remains inconsistent. Weconducted a systematic review and meta-analysis to quantify treatment effectson beta-cell preservation, glycemic control, and insulin requirements whileexamining time-dependent efficacy and safety profiles.

Methods

We searched PubMed, Embase, and Cochrane CENTRAL for randomizedcontrolled trials evaluating immunomodulatory interventions (teplizumab,otelixizumab, low-dose IL-2) in T1D patients. Primary outcomes includedC-peptide area under curve, HbA1c, and insulin requirements analyzed asstandardized mean differences (SMD) using random-effects models.Meta-regression examined time-dependent treatment attenuation.

Results

SUBMITTER: Biswas S 

PROVIDER: S-EPMC12636228 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature