Altered gut microbial functional pathways in people with irritable bowel syndrome enable precision health insights.

ABSTRACT:

Background

Functional gastrointestinal disorders present diagnostic and therapeutic challenges, and there is a strong need for molecular markers that enable early health insights and intervention. Herein, we present an approach to assess the gut microbiome with stool-based gut metatranscriptome data from a large adult human population (n = 80,570), using irritable bowel syndrome as an example that features both an abnormal gut microbiome and a spectrum of distinct conditions.

Methods

We develop a suite of eight gut microbial functional pathway scores, each of which represents the activity of a set of interacting microbial functional features (based on KEGG orthology) relevant to known gut biochemical activities. We use a normative approach within a subpopulation (n = 9,350)

SUBMITTER: Patridge E 

PROVIDER: S-EPMC12636233 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature