Biological Mechanisms Linking Social Adversity and Cognition.

ABSTRACT:

Objectives

Various studies have shown that social adversity, such as loneliness or low SES, are linked with worse cognitive outcomes, though underlying biological mechanisms remain unclear. This scoping review aims to summarize existing evidence on biological processes that may serve as mediators underlying this association.

Methods

Following PRISMA-ScR guidelines, studies measuring social adversity, cognition, and at least one biological mechanism were included. Results were summarized narratively and in tabular formats.

Results

Twelve studies (n = 12) examined links between social adversity, cognition, and biological mechanisms. Inflammation, allostatic load, genetics and genetic aging markers were the three main biological mechanisms identified as potential mediato

SUBMITTER: Liang A 

PROVIDER: S-EPMC12636236 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature