Thalamic Structural Connectivity Alterations in Essential Tremor Associated with REM Sleep Behaviour Disorder.

ABSTRACT:

Background

REM sleep behavior disorder (RBD) is a rare REM-parasomnia, now considered a non-motor symptom of Essential Tremor (ET). Distinct structural alterations in the thalamus, as a key region modulating REM sleep, have been reported in patients with idiopathic and Parkinson's disease-related forms. In this work, we investigated thalamic regions in ET patients with and without RBD, using a graph theoretical analysis.

Methods

MRI data were acquired from 96 participants (41 ET, 10 ET with polysomnographic-confirmed RBD, ET-RBD, 45 controls). T1-weighted scans were obtained, and grey matter volumes were estimated across 28 thalamic regions of the AAL3 template (Cat12 toolbox). An adjacency matrix for each group was calculated using Pearson correlation. Group-specific matric

SUBMITTER: Bortolin E 

PROVIDER: S-EPMC12636279 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature