Frequency-Dependent Modulation of the Prefrontal Cortex by Low-Intensity Focused Ultrasound: Impact on Mesolimbic Dopamine Signaling.

ABSTRACT: Synchronized neural oscillations are fundamental for cognitive function and orchestrate inhibitory and excitatory neurotransmission and downstream signaling. We hypothesized that low-intensity focused ultrasound (LIFU) with frequency parameters mimicking oscillatory patterns would enable targeted neuromodulation. Building on prior findings of the ability of LIFU to modulate neurotransmission, we investigated the effects of frequency-modulated LIFU applied to the prelimbic cortex (PLC) on dopamine release in the nucleus accumbens (NAcc) core as well as neuronal and astrocytic activity. After three 80-second LIFU stimulations spaced 30 minutes apart, we found that LIFU excited or inhibited NAcc dopamine release for up to 90 minutes, and these effects were dependent on oscillation frequency a

SUBMITTER: Olaitan GO 

PROVIDER: S-EPMC12636286 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature