Structural and Biophysical Basis for PFAS Binding by Human Sterol Carrier Protein-2.

ABSTRACT: Per- and polyfluoroalkyl substances (PFAS) are harmful environmental contaminants that bioaccumulate in human tissues and are linked to adverse health outcomes. While PFAS are known to bind to a variety of lipid binding proteins (LBPs), such as human serum albumin and fatty acid-binding proteins (FABPs), the broader molecular basis for their biological distribution and breadth of protein binding in humans remains unanswered. We hypothesize that some distribution and persistence of PFAS in humans arises from a distributed network of lipid transfer proteins that collectively solubilize and transport these compounds. To support this hypothesis, we investigated the interaction between various PFAS and human sterol carrier protein 2 (SCP2), a promiscuous, structurally distinct LBP with no previ

SUBMITTER: Birchfield AS 

PROVIDER: S-EPMC12636295 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature