A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences.

ABSTRACT: The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-motor integration, and a processing site for nociceptive information that eventually drives pain perception in the brain. Tremendous progress has been made in understanding spinal cord circuits using genetic and single cell sequencing approaches in mice. Recently, several groups have conducted single-nucleus and spatial sequencing studies in postmortem human spinal cord tissue. However, the spatial properties of spinal cord cellular diversity and potential sex differences that might be important for human physiology remain unexplored. We conducted deep single-nucleus sequencing on dissected lumba

SUBMITTER: Gabriel KA 

PROVIDER: S-EPMC12636303 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature