Video - Visual Integration of Drosophila Enhancer Organization: A tool for integrating and visualizing chromatin accessibility, in vivo transcription factor binding and motif occurrence in tissue-specific differentially expressed genes.

ABSTRACT: Dissecting gene regulation today relies on many genomic assays - including transcriptional output from RNA-seq, chromatin accessibility from ATAC-seq, and transcription factor (TF) binding from ChIP-seq. Whereas numerous tools exist for each modality and some integrate data across modalities, few allow researchers to interactively explore and visualize how TF binding motifs intersect with transcriptional activity and chromatin accessibility in a tissue-specific context. Here we introduce VIDEO (Visual Integration of Drosophila Enhancer Organization), a web-based analysis tool that enables visualization of conserved TF binding motifs within proximal promoters of genes differentially expressed in specific tissues. Starting with gene lists derived from in situ hybridization, microarray, and/o

SUBMITTER: Ajay V 

PROVIDER: S-EPMC12636324 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature