Engineering a Biomimetic Multiphasic Suture Anchor System for Enhanced Rotator Cuff Enthesis Regeneration.

ABSTRACT: Conventional suture anchor methods in rotator cuff repair often fail to replicate the native tendon-to-bone interface, leading to re-tears due to stress concentrations and poor biological integration at anchor sites. To address these challenges, we engineered a biomimetic multiphasic scaffold system (BMS) that integrates with standard suture anchors and deliver spatially organized structural and biological cues to enhance enthesis regeneration. The BMS comprises three distinct phases: aligned nanofibrous decellularized bovine Achilles tendon extracellular matrix (dECM) with 'stiff' methacrylated hyaluronic acid (MeHA) for tendon regeneration; nonaligned nanofibrous dECM with 'soft' MeHA for fibrocartilage formation; and a porous, citrate-based composite scaffold with bioactive glass for bo

SUBMITTER: Li Z 

PROVIDER: S-EPMC12636334 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature