Genetic analysis of potential biomarkers and therapeutic targets in hypoxia and pyroptosis from psoriasis.

ABSTRACT:

Background

Pyroptosis and hypoxia play pivotal roles in the onset and progression of psoriasis, though their interactions remain poorly understood. This study aims to clarify the involvement of pyroptosis-related genes (PRGs) and hypoxia-related genes (HRGs) in psoriasis pathogenesis.

Methods

Psoriasis-related datasets were analyzed alongside PRGs and HRGs. Differentially expressed genes (DEGs) between psoriasis and control samples were first identified. Expression levels of PRGs and HRGs were used to compute respective scores, which facilitated the identification of key module genes. Candidate genes were then derived by intersecting DEGs with key module genes. Biomarkers were selected using machine learning algorithms, gene expression analysis, and receiver operating charac

SUBMITTER: Cui J 

PROVIDER: S-EPMC12636341 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature