Dentate spikes comprise a continuum of relative input strength from the lateral and medial entorhinal cortex.

ABSTRACT: Hippocampal dentate spikes (DS) are synchronous population events generated in the dentate gyrus thought to support memory processing. DS are classified into type 1 (DS1) and type 2 (DS2) based on current sinks in the outer or middle molecular layer, where the axons of the lateral or medial entorhinal cortex terminate, respectively. This widely used classification method constrains DS into a bimodal distribution without properly testing whether such constraint is appropriate. Here we utilized silicon probe recordings with high spatial resolution spanning all layers of the dentate gyrus and discovered that the contribution of LEC/MEC inputs to DS follows a continuous distribution. We introduce a third type (DS3) that captures a previously unreported component of the distribution: simultaneo

SUBMITTER: Tarcsay G 

PROVIDER: S-EPMC12636346 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature