Blimp-1 benefits gut-homing regulatory T cells by maintaining migration/suppressive function in autoimmune diabetes-prone mice.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have shown that Crohn's disease (CD) and type 1 diabetes (T1D) are the top 2 diseases with the highest genetic risk variants and share several susceptible loci. Since both CD and T1D are T cell-mediated diseases, we hypothesise a mechanistic linkage between T-cell homeostasis and a gut-pancreas axis that differentially regulates the immunopathogenesis and development between CD and T1D.

Methods

Using data for 1 million people from a 16-year nationwide population-based databank in Taiwan, we unraveled a higher risk of prevalent inflammatory bowel disease in T1D patients. This observation is supported by our model of T-cell-specific B-lymphocyte-induced maturation protein 1 (Blimp-1) deficiency-induced colitis, in which more se

SUBMITTER: Tsai YW 

PROVIDER: S-EPMC12636379 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature