Analytical expectations for ancestry junction accumulation in admixed genomes.

ABSTRACT: Complex demographic events have shaped human history, leaving signatures of genetic variation across the genome. Here, we recover the recent evolutionary history of admixed populations formed from multiple ancestral sources. We present a discrete, generalizable model of admixture that leverages ancestry switches, which are recombination breakpoints that mark changes in ancestral origin along a chromosome. We derive analytical expectations for the number of ancestry switches within a genomic segment as functions of recombination rate, ancestry heterozygosity, and effective population size, and extend these expectations to incorporate population-specific recombination maps. Forward-time simulations tracing ancestry junctions for ten generations after admixture show close agreement with theor

SUBMITTER: Nataneli S 

PROVIDER: S-EPMC12636454 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature