Trimodal brain-wide ultrasound imaging of brain-tumor interaction.

ABSTRACT: Patients with brain tumors often suffer debilitating neurological dysfunction as their tumors disrupt brain tissue, affecting both local and global neural activity and blood flow. However, studying tumor-brain interactions in animal models is challenging due to a lack of methods that simultaneously capture dynamics of tumor growth, neural activity and vascular alterations over time. Here, we overcome this limitation using a multimodal ultrasound imaging platform, an imaging technique that offers brain-wide coverage in living animals at 10-100 μm resolution. To monitor the co-evolution of tumor growth, neural activity and vascular remodeling, we integrated (1) nonlinear imaging of acoustic reporter gene expressing-tumors, (2) hemodynamic functional imaging of brain activity, and (3) super-r

SUBMITTER: Rabut C 

PROVIDER: S-EPMC12636510 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature