Association between vaccinations and risk of dementia: a systematic review and meta-analysis.

ABSTRACT:

Importance

Dementia is a highly prevalent issue in older people. Whilst the prevention of dementia is a public health priority, the role of vaccinations is still largely unexplored.

Objective

The aim of this systematic review is to evaluate whether common adult vaccinations are associated with a reduced risk of dementia.

Data sources

PubMed, Embase and Web of Science were searched from inception to 1 January 2025.

Study selection

Observational studies comparing dementia and mild cognitive impairment incidence between vaccinated and unvaccinated adults aged ≥50 years.

Data extraction and synthesis

Four reviewers independently extracted data and assessed study quality using the Newcastle-Ottawa Scale. Risk ratios (RRs) and 95% confidence intervals (CIs) we

SUBMITTER: Maggi S 

PROVIDER: S-EPMC12636520 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature