Aneuploidy, polyploidy, and loss of heterozygosity distinguish serial bloodstream isolates of <i>Candida albicans</i>.

ABSTRACT:

Background

The opportunistic pathogen Candida albicans is the leading species causing invasive Candida infections worldwide. Genomic variation is widespread in clinical isolates and complicates identification of genetic variants underlying antifungal drug resistance and tolerance. Our understanding of genomic and phenotypic diversity during invasive infections is limited and studies of serial isolates from individual patients are uncommon. We performed comparative analyses of 101 C. albicans bloodstream isolates from 55 patients in the Minnesota Minneapolis-Saint Paul region, including serial isolates from 19 patients. We analyzed the phylogenetic relationships of these isolates relative to 199 globally-collected public C. albicans genomes.

Results

SUBMITTER: Scott NE 

PROVIDER: S-EPMC12636581 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature