Nanodomain formation in lipid bilayers II: The influence of mixed-chain saturated lipids.

ABSTRACT: An important class of lipids found in biological membranes are composed of two structurally different hydrocarbon chains. Among these, low-melting lipids possessing both a saturated and unsaturated chain have been intensely studied because of their biological abundance and influence on lipid rafts. In contrast, much less is known about the biophysical effects of mixed chains in high-melting lipids. Here, we investigated two such lipids-MSPC (14:0-18:0 PC) and SMPC (18:0-14:0 PC)-to determine how chain length mismatch and acyl chain position on the glycerol backbone influence lateral organization. We studied the temperature- and composition-dependent phase behavior of liposomes composed of either mixed-chain or symmetric-chain high-melting lipids plus DOPC and cholesterol, using techniques

SUBMITTER: Mehta D 

PROVIDER: S-EPMC12636591 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature