Sexual dimorphism in the complete connectome of the <i>Drosophila</i> male central nervous system.

ABSTRACT: Sex differences in behaviour exist across all animals, typically under strong genetic regulation. In Drosophila, fruitless/doublesex transcription factors can identify dimorphic neurons but their organisation into functional circuits remains unclear. We present the connectome of the entire Drosophila male central nervous system. This contains 166,691 neurons spanning the brain and nerve cord, fully proofread and annotated including fruitless/doublesex expression and 11,691 types. We provide the first comprehensive comparison between male and female brain connectomes to synaptic resolution, finding 7,205 isomorphic, 114 dimorphic, 262 male-specific and 69 female-specific types. This resource enables analysis of full sensory-to-motor circuits underly

SUBMITTER: Berg S 

PROVIDER: S-EPMC12636603 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature