Genome sequencing of 35,024 predominantly African ancestry persons addresses gaps in genomics and healthcare.

ABSTRACT: Genetic variation is crucial in human development, disease susceptibility, and drug response. Despite populations of African descent having the highest degree of genetic variation, genetic research has predominantly focused on populations of European descent, limiting potential for discovery. Recent studies of individuals with African ancestry have driven key medical advances benefiting all populations. Large scale, electronic health record (EHR) linked biobanks have provided opportunities to expand genetic research to larger and more diverse populations. We present initial results from the Alliance for Genomic Discovery (n = 35,024), in which 80% of participants have majority African ancestry, with genome sequencing and extensive phenotyping (median ~10 years of EHR data). We demonstrate

SUBMITTER: Avery C 

PROVIDER: S-EPMC12636650 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature