Short-Term Modulation of Epileptic Network with Low-Frequency Thalamic Stimulation.

ABSTRACT: Thalamic neuromodulation is an emerging therapeutic strategy for patients in whom resection of the epileptogenic zone is not feasible. Yet the mechanisms by which thalamic stimulation modulates epileptogenic network dynamics remain unclear. We designed this study to test whether brief thalamic stimulation transiently modulates cortico-cortical activity and coupling within patient-specific epileptic networks. We studied 10 patients undergoing stereo-EEG with sampling of the anterior or centromedian thalamic nuclei. During wakefulness, we delivered low-frequency single pulse stimulations at 1 Hz and compared post-stimulation epochs (15-900 ms) with a pre-stimulation baseline. We quantified band-limited spectral power and Granger causality between bipolar cortical contacts, focusing on slow (

SUBMITTER: Kanai S 

PROVIDER: S-EPMC12636673 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature