Anti-inflammatory reliever therapy for asthma using inhaled budesonide/formoterol as-needed with or without maintenance in South African children (AIR-SA 001): a description of a randomised clinical trial protocol.

ABSTRACT:

Background

Asthma is the most common non-communicable disease among children, with increasing prevalence. The current standard of care in high-income countries in adults and adolescents includes the use of combination inhaled corticosteroids (ICSs) with rapid-onset long-acting ß₂ agonists (LABA) for all severities of asthma. The primary objective of this trial is to assess the efficacy of a budesonide/formoterol inhaler used 'both as required, and regularly' to reduce asthma exacerbations compared with the standard of care for asthma in children and adolescents.

Methods

Children and adolescents aged 6-18 years with a diagnosis of asthma with at least one asthma exacerbation in the previous 12 months will be randomised to receive either budesonide/formoterol inhale

SUBMITTER: Hlophe ST 

PROVIDER: S-EPMC12636877 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature