Oncolytic virus-induced IL-1β⁺ monocyte-IL-6⁺ CAF axis suppresses dendritic cell-mediated antitumor immunity in pancreatic cancer.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a profoundly immunosuppressive tumor microenvironment, which features a dense desmoplastic stroma enriched with cancer-associated fibroblasts (CAFs) that collectively impede the efficacy of immunotherapies. Although oncolytic viruses (OVs) have demonstrated promising potential in eliciting antitumor immunity, the mechanisms by which stromal components modulate OV efficacy remain poorly understood.

Methods

To investigate the interplay between immune and stromal components in PDAC following OV treatment, we employed murine and patient-derived tumor models. We characterized immune cell populations using single-cell RNA sequencing and flow cytometry. Functional studies included the engineering of a next-gener

SUBMITTER: Li F 

PROVIDER: S-EPMC12636881 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature