Systemic administration of <i>Photobacterium angustum</i> promotes antitumor immunity and direct tumor lysis in murine models of colorectal cancer.

ABSTRACT:

Background

Despite remarkable advances in cancer immunotherapy, including immune checkpoint inhibitors and adoptive cell therapies, many patients fail to achieve durable responses due to factors such as immunosuppressive tumor microenvironments, poor tumor antigenicity, and systemic toxicity. These limitations underscore the need for alternative platforms that can elicit robust and localized antitumor immune responses. Bacteria have emerged as promising candidates owing to their natural ability to selectively colonize tumors, stimulate innate and adaptive immunity, and be engineered for therapeutic delivery. However, the therapeutic potential of naturally occurring marine bacterial strains remains largely unexplored in colorectal cancer.

Methods

We screened a panel of marine

SUBMITTER: Miyahara M 

PROVIDER: S-EPMC12636898 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature