Development and validation of nomograms for predicting activity index and tubulointerstitial lesions in lupus nephritis: a multicentre study.

ABSTRACT:

Objective

Lupus nephritis (LN) is a prevalent renal manifestation in patients with SLE, with kidney biopsy remaining the gold standard for evaluating disease activity. However, the invasive nature of biopsy and associated risks highlight the need for a non-invasive predictive tool. This study aimed to construct and validate predictive models for the activity index (AI) and tubulointerstitial lesions (TIL) in patients with LN as an alternative tool to assist clinicians in decision-making when kidney biopsy is not feasible.

Methods

We enrolled 266 patients with LN diagnosed by kidney biopsy from three centres, divided into a training cohort (n=213) and a validation cohort (n=53). Patients were stratified by AI and TIL scores: high AI (AI >4), low AI (AI ≤4), high TIL (TIL >4)

SUBMITTER: Lin Z 

PROVIDER: S-EPMC12636907 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature