Non-invasive liver fibrosis scores and mortality in a cohort of World Trade Center rescue/recovery workers.

ABSTRACT:

Objectives

Higher liver fibrosis scores have been associated with all-cause and liver disease-related mortality. We investigated whether liver fibrosis scores were associated with all-cause, liver disease-related and non-liver disease-related mortality and liver cancer incidence in an occupational cohort.

Methods

The study included 43 870 Combined World Trade Center Rescue/Recovery Worker Cohort members who had blood drawn between 11/9/2001-31/12/2020. Aspartate aminotransferase to platelet ratio index (APRI), fibrosis-4 score (FIB-4), and non-alcoholic fatty liver disease fibrosis score (NFS) were calculated and categorised as low, intermediate or high scores per established cut-offs. Deaths and liver cancers were identified via National Death Index records and state cancer

SUBMITTER: Singh A 

PROVIDER: S-EPMC12636936 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature